Whenever Etrata deals combat damage to a player, exile target creature that player controls and put a hit counter on that card. That player loses the game if they own three or more exiled cards with hit counters on them. Etrata's owner shuffles Etrata into their library.
Connect with the unblockable Etrata to exile an opponent's creature with a hit counter; landing three hits on one player kills them outright, ignoring life totals. After each hit she shuffles into your library, so you cast or tutor her back and repeat, while protecting her swings and accelerating her recursion.
Alternate, life-total-independent win condition that bypasses big board states and lifegain
Etrata is innately unblockable, making combat damage reliable
Self-shuffle protects her from being countered/killed in response after a hit
Doubling or extra-damage effects can land multiple hit counters in one turn
Slow clock: you need three connections, often spread or focused, before the kill
Hit counters track per owner, so hitting multiple opponents delays any single kill
Reshuffling Etrata makes her unreliable to find without tutors and card draw
Vulnerable to unblockable-hate, fog effects, and graveyard/exile interaction is irrelevant but flicker can reset her
Removal in response to her trigger still lets the creature exile but you lose tempo